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Advaxis Expands Intellectual Property for Lm Technology(TM) Platform in HER2

21-Jul-2015 | Source : Advaxis | Visits : 6444
PRINCETON, N.J. - Advaxis Inc., a clinical-stage biotechnology company developing cancer immunotherapies, today announced in a press release that the United States Patent and Trademark Office (USPTO) has granted US Patent No. 9,084,747 with composition of matter claims covering ADXS-HER2. The patent expands Advaxis's intellectual property portfolio in claiming numerous compositions for the company's Lm Technology™ immunotherapy candidate designed to target HER2 expressing cancers. The patent also covers methods of using the same compositions for eliciting an immune response against, preventing the onset of, preventing the formation of, impeding a growth of, preventing an escape mutation in the treatment of, or treating a HER2 expressing tumor.

The patent will expire on September 19, 2032, and also covers ADXS-HER2 use for decreasing the frequency of intra-tumoral T regulatory cells, for decreasing the frequency of myeloid derived suppressor cells, or for increasing intratumoral ratio of CD8+/ T regulatory cells.

"We see significant potential for our investigational agents in HER2 expressing cancers," said Daniel J. O'Connor, President and Chief Executive Officer of Advaxis. "This patent rounds out our portfolio, allowing us to maintain the development of ADXS-HER2 and commence enrollment of the first human trial as planned by year end."
Currently, Advaxis has 29 granted patents and 37 pending applications in the United States, in addition to having 54 granted foreign patents and 60 pending foreign applications.

Human epidermal growth factor receptor 2 (HER2) is expressed in a percentage of solid tumors such as breast, gastric, bladder, brain, pancreatic, ovarian and pediatric bone cancer (osteosarcoma). The American Cancer Society estimates that in 2015 in the United States alone there will be 231,840 new cases of invasive breast cancer; 24,590 new cases of gastric cancer; 74,000 new cases of bladder cancer; 22,850 new cases of brain/spinal cancer; 48,960 new cases of pancreatic cancer; 21,290 new cases of ovarian cancer; and 207 new cases of pediatric osteosarcoma. HER2 expression is associated with more aggressive disease, increased risk of relapse and decreased overall survival, and is an important target for immunotherapy.

ADXS-HER2 is an Lm Technology™ immunotherapy product candidate being developed by Advaxis for the targeted treatment of HER2 expressing cancers. ADXS-HER2 has received orphan drug designation by the U.S. Food and Drug Administration (FDA) for the treatment of osteosarcoma in May 2014. Advaxis is developing ADXS-HER2 for both human and animal-health, and has seen encouraging data in canine osteosarcoma, which is considered a model for human osteosarcoma. Advaxis has licensed ADXS-HER2 and three other immunotherapy constructs to Aratana Therapeutics, Inc. for pet therapeutics.

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